NALT: N-Acetyl L-Tyrosine
NALT (which is short for N-Acetyl L-Tyrosine) is a derivative of L-Tyrosine as the N-Acetyl is added to it to improve the absorption of L-Tyrosine. The letter is an amino acid which among other things helps your body produce dopamine. The N-Acetyl is an acetic acid which not only increases absorption of L-Tyrosine but also has a potentially desirable effect of additionally increasing the synthesis of dopamine as well as promoting generation of new cells. Despite this additional effect of N-Acetyl the main benefit of NALT over L-Tyrosine is that it is more lipophilic thus easier to absorb.
Since it increases dopamine levels the main effect of NALT is that it creates a positive feeling – good mood. This usually also decreases anxiety and instills a sense of calmness in you, which helps manage stress.
As dopamine levels increase some people experience a great boost of focus and motivation. While this goes somewhat against the theory of how humans (and animals) function, the effect might be explained by presuming that those people who experience such effect are naturally deficient in dopamine. In fact some studies say that the majority of population could benefit from supplementing with L-Tyrosine or NALT.
But these studies are disputed by the fact that around half of people who take NALT experience no effect. Interestingly slightly more people feel positive effects from L-Tyrosine than from NALT which confirms some studies which indicate that N-Acetyl L-Tyrosine is actually less bio-available than plain L-Tyrosine. However all this has another twist as most NALT users who do feel effects report much stronger and more intense effects from NALT than from L-Tyrosine. This is just another example of how complex is the science of nootropics – it is difficult to determine what works for a specific individual until he tries it.
Dose and side effects of NALT
NALT doses vary between 250 and 450 mg one to two times per day and are recommended not to exceed 1 gram per day.
As long as you stay within the recommended doses there are few if any side effects associated with N-Acetyl L-Tyrosine. Most common reports are headaches and gastrointestinal distress. However if you take too high doses migraines, severe diarrhea and gastrointestinal pain are possible. To avoid this start with half doses to see how your body reacts.
N-Acetyl L-Tyrosine is often reported to be better tolerated than L-Tyrosine which is believed to be due to the additional processes the molecule undergoes in the body.
One possibly unwanted effect of NALT is that it increases levels of Norepinephrine which is produced by adrenal glands. While this is desired by most people as it gives a feeling of focus and energy it might be an unwanted effect if you have adrenal fatigue.
Tolerance build-up and withdrawal potential of N-Acetyl L-Tyrosine
There are no data showing that NALT would cause tolerance buildup or physical dependence however due to its nature (promotes dopamine production) it is conceivable that it might cause at least some psychological dependence. To avoid this cycle off of N-Acetyl L-Tyrosine periodically.
Like with any stimulant there is a possibility that NALT might cause up-regulation of the receptors its derivatives affect. While there have not been any studies showing that it is best to avoid this with cycling off of N-Acetyl L-Tyrosine periodically.
Buying and stacking NALT
NALT is a very cheap nootropic thus there are no (at the moment) known schemes associated with it. Nevertheless you should buy N-Acetyl L-Tyrosine from a trustable source to ensure you get a pure and high quality product.
The biggest benefits from N-Acetyl L-Tyrosine will probably see those who are deficient in dopamine, but others may see some benefits as well especially those who use stimulants like caffeine.
As NALT helps replenish dopamine levels after stimulant use it is sometimes used to help with comedowns and withdrawals. Also it is often stacked with other nootropics to create a more potent nootropic stack with long duration. One such stack contains the following: